Antioncogenic Activity of Influenza Virus on Polyoma Virus Induced Renal and Brain Tumors in Newborn Wistar Rats

G. Noss , G. Stauch
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引用次数: 2

Abstract

Simultaneous inoculation of newborn Wistar rats with intact A/PR 8/34 (HON1) influenza virus and the S.E. strain of polyoma virus resulted in significant reduction of the rates of both kidney sarcomas and brain tumors in comparison to controls given polyoma virus, only. This antioncogenic activity (AOA) of influenza virus was observed independently whether or not influenza and polyoma virus were injected on different sites or were inoculated as a combined vaccine. Ether-treated A/PR 8/34 influenza virus was found to have also AOA. However, in one experiment a significant AOA was demonstrated with respect to brain tumors, only, and not for the rate of renal sarcomas. In addition, the influenza strain A/Hong Kong/1/68 (H3N2) was found to have AOA.

流感病毒对新生Wistar大鼠多瘤病毒诱导的肾和脑肿瘤的抗逆性活性
新生Wistar大鼠同时接种完整的A/PR 8/34 (HON1)流感病毒和S.E.多瘤病毒株,与只接种多瘤病毒的对照组相比,肾脏肉瘤和脑肿瘤的发生率均显著降低。无论流感病毒和多瘤病毒是否在不同部位注射或作为联合疫苗接种,均独立观察到流感病毒的抗原性活性(AOA)。经乙醚处理的A/PR 8/34型流感病毒也存在AOA。然而,在一项实验中,AOA仅在脑肿瘤中被证明是显著的,而在肾肉瘤中没有。此外,流感病毒株A/Hong Kong/1/68 (H3N2)亦有AOA。
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