INTERACTIONS OF ANTICANCER DRUGS – ABIRATERONE AND GALETERONE – WITH CYTOCHROME P450 51A1 (CYP51A1)

http://eng.biomos.ru/conference/articles.htm Pub Date : 2021-01-01 DOI:10.37747/2312-640x-2021-19-149-150

A. Kuzikov, A. Veselovsky, I. Toropygin, A. Archakov, V. Shumyantseva

引用次数: 0

Abstract

Interactions of abiraterone and galeterone with steroid-metabolizing cytochrome P450 (CYP51A1) was studied. Binding of substrate type was observed, which indicates possible metabolism of abiraterone and galeterone by CYP51A1, however electrocatalytic reaction only towards abiraterone was observed.

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抗癌药物阿比特龙和加莱酮与细胞色素p450 51a1 (cyp51a1)的相互作用

研究了阿比特龙和加勒酮与类固醇代谢细胞色素P450 (CYP51A1)的相互作用。观察到底物类型的结合，表明CYP51A1可能对阿比特龙和galeterone进行代谢，但只对阿比特龙进行电催化反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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http://eng.biomos.ru/conference/articles.htm

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