Bio-physical investigation of calcium silicate biomaterials by green synthesis- osseous tissue regeneration

IF 0.7 4区 材料科学 Q4 METALLURGY & METALLURGICAL ENGINEERING
S. S. Muthulakshmi, S. Shailajha, B. Shanmugapriya, Hap Hydroxyapatite
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引用次数: 1

Abstract

CaSiO3 wollastonite biomaterials were synthesized by hydrothermal approach in three different weight percentages of SiO2 and CaO (CA—25:75, CB—50:50, and CC—75:25) extracted from silica sand and limestone. In vitro biological testing revealed the materials bioactivity in SBF and their antibacterial efficacy against Streptococcus aureus and Escherichia coli. By direct contact with the L929 mouse fibroblast cell line, the cell viability against synthesized biomaterials was examined. These bio-properties were interlinked with the degradation rate of biomaterials in biofluid, which was observed under Tris–Hcl immersion. The regulated degradation of synthesized biomaterial simultaneously constrained the alkaline pH shift, which is beneficial for bioactivation and biocompatibility. It attained a compressive strength of 73 MPa without failure, which is equivalent to or higher than conventional bioglass and suitable for load-bearing sites. The synthesized biomaterials acquire excellent bioactivity, biocompatibility, and mechanical stability through controlled degradation versus bone apatite formation in a balanced manner, supported by porously fused structure.
绿色合成硅酸钙生物材料骨组织再生的生物物理研究
采用水热法从硅砂和石灰石中提取不同重量百分比的SiO2和CaO (ca: 25:75, cb: 50:50, CC-75:25),合成了CaSiO3硅灰石生物材料。体外生物学试验显示了该材料在SBF中的生物活性及其对金黄色链球菌和大肠杆菌的抑菌作用。通过直接接触L929小鼠成纤维细胞系,检测细胞对合成生物材料的活性。这些生物特性与生物材料在生物流体中的降解率相关,这是在Tris-Hcl浸泡下观察到的。合成的生物材料在调节降解的同时,抑制了碱性pH的变化,有利于生物活化和生物相容性。抗压强度达到73 MPa而不破坏,与传统生物玻璃相当或更高,适用于承重场所。合成的生物材料在多孔融合结构的支持下,通过平衡的方式控制降解和骨磷灰石形成,获得了优异的生物活性、生物相容性和机械稳定性。
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来源期刊
CiteScore
1.30
自引率
12.50%
发文量
119
审稿时长
6.4 months
期刊介绍: The International Journal of Materials Research (IJMR) publishes original high quality experimental and theoretical papers and reviews on basic and applied research in the field of materials science and engineering, with focus on synthesis, processing, constitution, and properties of all classes of materials. Particular emphasis is placed on microstructural design, phase relations, computational thermodynamics, and kinetics at the nano to macro scale. Contributions may also focus on progress in advanced characterization techniques. All articles are subject to thorough, independent peer review.
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