The inhibition effect of etidronate on degradation behavior of Mg–Zn–Y-Nd-Zr alloy

Smart Materials in Manufacturing Pub Date : 2024-01-01 DOI:10.1016/j.smmf.2023.100020

Di Mei, Yaqian Li, Xiaoshuang Ma, Liguo Wang, Shijie Zhu, Shaokang Guan

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Abstract

The control of corrosion behavior of Mg alloys for biomedical applications is a research hotspot in the field of biodegradable metallic implant materials. In recent years, the employment of corrosion inhibitors for regulating the corrosion behavior of Mg alloys has attracted attention. In this work, a promising corrosion inhibitor for Mg alloys, Etidronate (ETN), was selected from the drugs for the treatment of osteoporosis, and its effect on the corrosion behavior of Mg–Zn–Y-Nd-Zr (ZE21C Mg alloy) in simulated body fluids was systematically studied. The results show that ETN not only reduces the corrosion rate of the alloy, but also significantly weakens its tendency of localized corrosion, which is beneficial for improving the service reliability of Mg alloy for orthopedic application. This study provides an idea for corrosion control of biodegradable Mg alloys and is of great significance for promoting their development and applications.

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依替膦酸盐对 Mg-Zn-Y-Nd-Zr 合金降解行为的抑制作用

控制生物医学应用中镁合金的腐蚀行为是可生物降解金属植入材料领域的一个研究热点。近年来，使用缓蚀剂来调节镁合金的腐蚀行为引起了人们的关注。本研究从治疗骨质疏松症的药物中选取了一种很有前景的镁合金缓蚀剂--依替膦酸盐（ETN），并系统研究了它对模拟体液中 Mg-Zn-Y-Nd-Zr （ZE21C 镁合金）腐蚀行为的影响。结果表明，ETN 不仅能降低合金的腐蚀速率，还能显著削弱其局部腐蚀倾向，有利于提高骨科用镁合金的使用可靠性。这项研究为可生物降解镁合金的腐蚀控制提供了一种思路，对促进可生物降解镁合金的开发和应用具有重要意义。

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