A Fully Transparent, Flexible μECoG Array Based on Highly Conductive and Anti-reflective PEDOT:PSS-ITO-Ag-ITO Thin Films

Weiyang Yang, Q. Fan, Wen Li
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引用次数: 4

Abstract

Integrative neural interfaces combine neurophysiology and optogenetics with neural imaging, providing numerous opportunities for neuroscientists to study the structure, function, and diseases in neural circuits. Such a comprehensive interface demands miniature electrode arrays that are highly transparent, mechanically flexible, and biocompatible. Compared to implanted electrodes, microscale electrocorticogram (μECoG) arrays are less invasive, therefore lowering the risk of infection, seizure, and stroke. Common transparent μECoG arrays are made of a single material and at most two materials, including indium tin oxide (ITO), ultrathin metals, graphene, poly-(3, 4-ethylenedioxythiophene)/ poly(styrenesulfonate) (PEDOT:PSS), etc. , making it hard to possess the excellent combination of properties, like high transmittance, low electrical resistance, mechanical flexibility, stability, and biocompatibility. In this paper, we structured an ultra-flexible, fully transparent, highly conductive, and peak-transmittance-tunable μECoG array with a PEDOT:PSS-ITO-Ag-ITO multilayer assembly on a thin Parylene C substrate. Each array consisted of 32 transparent microelectrodes distributed uniformly and divided equally into two 5 mm× 11 mm panels. The transmittance of the PEDOT:PSS-ITO-Ag-ITO assembly under the 550 nm targeted wavelength on the Parylene C substrate was ~7% higher than that of a single ITO layer of the equivalent thickness. The average impedance of the microelectrodes at 1 kHz was ~45 kΩ and increased to ~59 kΩ after four weeks of soaking test, suggesting the stability of the electrodes for long-term electrophysiology recording. Cyclic voltammetry was performed to confirm the increased charge storage capacity. These microelectrodes based on PEDOT:PSS-ITO-Ag-ITO also showed a neglectable signal-to-noise ratio (SNR) changes under blue, green, yellow and red light-emitting diodes (LEDs) compared with no light. In vivo recording from the primary visual cortex (V1) of an anesthetized rat validated the efficacy of the transparent electrodes for recording ECoG activity in living brain tissues.
基于高导电抗反射PEDOT:PSS-ITO-Ag-ITO薄膜的全透明柔性μECoG阵列
综合神经接口将神经生理学和光遗传学与神经成像相结合,为神经科学家研究神经回路的结构、功能和疾病提供了许多机会。这样一个全面的界面需要高度透明、机械柔性和生物相容性的微型电极阵列。与植入电极相比,微尺度皮质电图(μECoG)阵列的侵入性较小,因此降低了感染、癫痫发作和中风的风险。常见的透明μECoG阵列是由一种或最多两种材料制成的,包括氧化铟锡(ITO)、超薄金属、石墨烯、聚(3,4 -乙烯二氧噻吩)/聚(苯乙烯磺酸盐)(PEDOT:PSS)等,很难同时具备高透光率、低电阻、机械柔韧性、稳定性和生物相容性等优异的综合性能。在本文中,我们用PEDOT:PSS-ITO-Ag-ITO多层组件构建了一个超柔性、全透明、高导电性、峰值透射率可调的μECoG阵列。每个阵列由32个均匀分布的透明微电极组成,平均分为两个5毫米× 11毫米的面板。PEDOT:PSS-ITO-Ag-ITO组件在聚对二甲苯基板上550 nm目标波长下的透过率比同等厚度的单一ITO层高出约7%。微电极在1 kHz时的平均阻抗为~45 kΩ,经过4周的浸泡试验后,平均阻抗增加到~59 kΩ,表明电极具有长期电生理记录的稳定性。循环伏安法证实了增加的电荷存储容量。这些基于PEDOT:PSS-ITO-Ag-ITO的微电极在蓝色、绿色、黄色和红色发光二极管(led)下的信噪比(SNR)变化与无光相比可以忽略不计。麻醉大鼠初级视觉皮层(V1)的体内记录证实了透明电极记录活体脑组织ECoG活动的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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