Association of Apolipoprotein A Gene Polymorphism with Uncomplicated Plasmodium falciparum Malaria in Elfasher City, North Darfur, Sudan

Alaa Abdallah Adam Idrise, Amanda Elgoraish, Rania TagElsir Ahmed, N. Omer, M. Salih, Jamal Ismail Khalifia Ismail, N. Adam, S. Elzaki
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Abstract

Aims: This study aimed to investigate the lipids profile, APOA genotype with malaria infection. It was hypothesized that the malaria parasite uses cholesterol and phospholipids from its host, resulting in a decrease in serum HDL. Study Design: A cross-sectional hospital -based study.  Place and Duration of Study: The study was conducted during the transmission season between July to November 2020 in different hospitals and centers in Elfasher city. Methodology: We included (39 men and 64 female), 57.3% were adults and 42.7% were children, plasmodium falciparum infection, with clinical symptoms and signs of uncomplicated malaria. Parasites density, lipids profile and APOA genotyping were assayed. Results: The mean level of CHOL and TG was 134.7 mg/dl and 73.0 mg/dl, respectively, and the average levels of LDL and HDL are 56.6 mg/dl and 56.2 mg/dl, respectively. The G/G genotypes of APOA were identified in 94.2% of the patients compared to other APOA genotypes. The overall allele frequency for the G allele was 96.0%, and the T allele was 3.9% using the Hardy-Weinberg distribution. Conclusion: In conclusions, the lipids profile and APOA genotype were not associated with uncomplicated malaria.
苏丹北达尔富尔elfaher市载脂蛋白A基因多态性与单纯恶性疟原虫疟疾的关系
目的:研究疟疾感染人群的脂质谱、APOA基因型。据推测,疟原虫利用宿主体内的胆固醇和磷脂,导致血清高密度脂蛋白下降。研究设计:以医院为基础的横断面研究。研究地点和时间:该研究于2020年7月至11月的传播季节在埃尔法希尔市的不同医院和中心进行。方法:我们纳入(男性39人,女性64人),成人57.3%,儿童42.7%,恶性疟原虫感染,临床症状和体征为无并发症的疟疾。测定寄生虫密度、脂质谱和APOA基因分型。结果:CHOL、TG均值分别为134.7 mg/dl、73.0 mg/dl, LDL、HDL均值分别为56.6 mg/dl、56.2 mg/dl。与其他APOA基因型相比,94.2%的患者鉴定出APOA的G/G基因型。使用Hardy-Weinberg分布,G等位基因的总等位基因频率为96.0%,T等位基因的总等位基因频率为3.9%。结论:脂质谱和APOA基因型与非复杂性疟疾无相关性。
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