Soluble Epoxide Hydrolase: Potential Target for Inflammation and Inflammation-Driven Cancer

Journal of carcinogenesis & mutagenesis Pub Date : 2017-05-22 DOI:10.4172/2157-2518.1000294

Chao Lou, Liping Zhang, Xiaobin Wang, Xiaoping Ma, Cuiyun Qin, Wei Li, Ting Jia, Qing-ling Nan, R. Qiang

引用次数: 1

Abstract

Arachidonic acid can be catalyzed by three different kind of metabolizing enzyme: cyclooxygenase (COX), lipoxygenase (LOX) and/or cytochrome P450 (CYP), and they produce prostaglandins, monohydroxys, leukotrienes and epoxyeicosanoids respectively. Through the cytochrome P450 pathway, arachidonic acid can be converted to two kinds of eicosanoid acids: epoxyeicosanoids acid (EET) by cytochrome P450 and hydroxyeicosatetraenoic acids (HETEs) formed by CYP α-oxidases.

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可溶性环氧化物水解酶:炎症和炎症驱动的癌症的潜在靶点

花生四烯酸可被环氧合酶(COX)、脂氧合酶(LOX)和/或细胞色素P450 (CYP)三种不同的代谢酶催化，分别生成前列腺素、单羟基、白三烯和环氧二十烷。通过细胞色素P450途径，花生四烯酸可转化为两种类二十烷酸:由细胞色素P450转化为环氧类二十烷酸(EET)和由CYP α-氧化酶形成的羟基二十烷酸(HETEs)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of carcinogenesis & mutagenesis

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