Lack of an Exposure Response and Interaction with HLA-DPβ1 and DRβ1 Polymorphisms in the Development of Beryllium Toxicity in a High Beryllium Exposure Cohort.

Q1 Medicine

International Journal of Occupational and Environmental Medicine Pub Date : 2019-11-15 DOI:10.1097/JOM.0000000000001766

V. Widyaningsih, K. Rosenman, M. J. Reilly, Ling Wang, D. Pathak, J. Gardiner, C. Rice, D. Monos, M. Rossman

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引用次数: 1

Abstract

OBJECTIVE To evaluate interaction of HLA-DPβ1 and DRβ1 polymorphisms with metrics of beryllium exposure, in the development of beryllium sensitization (BeS) and chronic beryllium disease (CBD). METHODS A matched case-control study of 61 CBD, 41 BeS, and 259 controls from two beryllium-processing facilities. RESULTS BES and CBD were significantly associated with presence of DPβE69. Dose response of exposure was not observed for the development of BES and CBD with/without adjustment for DPβE69 (p > 0.05). The DRβE71 polymorphism was more common in BeS than CBD after adjusting for exposure and maybe a protective factor (aOR 0.4, 95% CI 0.2-0.9) against the progression of BeS to CBD. CONCLUSION No exposure-response association was found, which may reflect that the workers in this high exposure cohort were above a threshold level where an exposure-response could be observed.

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在高铍暴露队列中，暴露反应的缺乏以及HLA-DPβ1和DRβ1多态性在铍毒性发展中的相互作用。

目的探讨HLA-DPβ1和DRβ1多态性在铍致敏(BeS)和慢性铍病(CBD)发展过程中与铍暴露指标的相互作用。方法对来自两家铍加工厂的61例CBD、41例BeS和259例对照进行匹配病例对照研究。结果bes和CBD与DPβE69的存在显著相关。在DPβE69调节和未调节的情况下，未观察到暴露对BES和CBD的剂量反应(p > 0.05)。调整暴露后，DRβE71多态性在BeS中比CBD中更常见，可能是阻止BeS向CBD发展的保护因素(aOR为0.4,95% CI为0.2-0.9)。结论未发现暴露-反应相关，这可能反映了该高暴露队列的工人超过了可观察到暴露反应的阈值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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