Luca Ginnari-Satriani, V. Casagrande, A. Alvino, Alessandro Altieri, Pierre Murat, E. Defrancq, C. Lombardo, S. Neidle, A. Bianco, G. Ortaggi, M. Franceschin
{"title":"Effects of Protein Binding on DNA G-Quadruplex Structures","authors":"Luca Ginnari-Satriani, V. Casagrande, A. Alvino, Alessandro Altieri, Pierre Murat, E. Defrancq, C. Lombardo, S. Neidle, A. Bianco, G. Ortaggi, M. Franceschin","doi":"10.15866/IREBIC.V2I4.1525","DOIUrl":null,"url":null,"abstract":"We report here a study of the binding affinity of a triazatruxene based G-quadruplex ligand and three derivatives to G-quadruplex structures and their selectivity with respect to duplex DNA. The parent compound AZATRUX is the best compound of the series, both in terms of affinity and selectivity","PeriodicalId":14377,"journal":{"name":"International Review of Biophysical Chemistry","volume":"16 1","pages":"135-141"},"PeriodicalIF":0.0000,"publicationDate":"2011-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Review of Biophysical Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15866/IREBIC.V2I4.1525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We report here a study of the binding affinity of a triazatruxene based G-quadruplex ligand and three derivatives to G-quadruplex structures and their selectivity with respect to duplex DNA. The parent compound AZATRUX is the best compound of the series, both in terms of affinity and selectivity
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