Pressurized pharmaceutical aerosols for inhalation therapy. II. Analytical control methods.

Abstract

Abstracr Analytical procedures for the control of pressurized aerosols for inhalation therapy require techniques not usually encountered in other dosage forms. Procedures are described for assay of active ingredients, amount of medication delivered per dose, and moisture content. Claims for improved stability of epinephrine and isoproterenol in this new dosage form are supported by data obtained from chemical and biological stability studies. Uniformity of dosage delivered from the aerosol valve and from the adapter was determined by chemical analyses and found to be well within the acceptable limits for other dosage forms.