Joanna A Ruszkiewicz, Alexander Bürkle, Aswin Mangerich
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引用次数: 0
Abstract
NAD+ is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD+ in mechanisms promoting genome maintenance. Numerous NAD+-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD+ serves as a substrate to ADP-ribosyltransferases, sirtuins, and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD+ levels.
期刊介绍：
Toxicology and Environmental Health Sciences (ToxEHS) publishes original research and reviews in all areas of fundamental and applied research relating to the toxicity of chemicals, nanoparticles and drugs at the molecular and cellular level in human and all model living system by all routes of exposure and in vitro / ex vivo. Focus is on risk assessment, environmental toxicology and environmental health as applied to humans (including epidemiological studies) and all the model organisms (including fish to mammal). In addition Toxicology and Environmental Health Sciences (ToxEHS) also publishes analytical method and development studies including biosensor and lab-on-a-chip, addressing important or topical aspect of toxicity of environmental and health toxicants and diagnosis. Special emphasis is given to papers of clear relevance to human health and regulatory environmental/ chemical/ nanoparticle toxicology.The Journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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