Les phospholipides de la cellule hépatique. Interprétation fonctionnelle de leur renouvellement

Abstract

Study at the subcellular level of the renewal of the hepatic phospholipid fatty acids by the endogenous fatty acids shows particularly the activity of the free fat phsophoglycerides. The fact that the incorporation intensities, the fastest for palmitic acid (half-life about 3 h), are similar, is in accordance with rapid intracellular exchanges.

The renewal of only the fatty acids in the phosphoglycerid molecule satisfies a function of intracellular transfer of fatty acids. The slower renewal of the intact molecule, joined to the renewal of the proteins, suggests a mechanism of disintegration and rebuilding of the membranes (endoplasmic reticulum and mitochondria) which leads to equilibrium of the cellular lipoproteins and permits entrance to the metabolites.