Efficacy of Helicobacter pylori eradication on recovery of chronic urticaria

M. Rafeey, Bozorgmehr Nasir, Z. Jalali, Nazanin Hazhir Karzar, M. Sadeghi-shabestari
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引用次数: 1

Abstract

Introduction: The studies have been equivocal about the association of Helicobacter pylori infection with chronic urticaria (CU) given some controversial evidence in recovery of urticaria following H. pylori eradication. Methods: In this clinical trial, 120 patients between the ages of 4 and 20 with intractable CU were recruited. They were grouped into two categories based on urea breath test (UBT) result. UBT positive group received treatment and UBT was repeated after two months while being evaluated for clinical course over a six-month period. On the other hand, UBT negative group received standard treatment for urticaria. Results: All participants with CU have been studied as 40 cases of UBT positive and 80 cases of control group with negative UBT, consisted of 42 (35%) male and 78 (65%) female. Patients had suffered from urticaria on average 29.9 (±26.6) months prior to diagnosis. Statistically significant difference was noted between two groups, in terms of severity of urticaria, frequency of episodes, abdominal pain and duration of being symptomatic prior to diagnosis. After receiving treatment for H. pylori infection, among case group, 27(67.5%) of individuals achieved complete recovery of urticaria and 13 (32.5%) cases demonstrated partial resolution of urticaria, meanwhile 59 cases (73.8%) of control group became completely symptom-free, while 21 (26.3%) of the remaining individuals were in incomplete recovery. In comparison of response to treatment between the above-mentioned groups, there was not any statistically significant difference (P=0.47) Conclusion: Our findings reveal that H. pylori infection might contribute to developing CU which highlights the significance of H. pylori eradication as an approach for CU.
幽门螺杆菌根除治疗慢性荨麻疹疗效观察
关于幽门螺杆菌感染与慢性荨麻疹(CU)之间的关系,研究一直不明确,在幽门螺杆菌根除后荨麻疹的恢复方面有一些有争议的证据。方法:本临床试验招募年龄在4 ~ 20岁的顽固性CU患者120例。根据尿素呼气测试(UBT)结果将他们分为两类。UBT阳性组接受治疗,2个月后重复UBT治疗,6个月后评估临床病程。另一方面,UBT阴性组接受标准的荨麻疹治疗。结果:所有CU参与者被研究为40例UBT阳性和80例UBT阴性对照组,其中男性42例(35%),女性78例(65%)。患者在诊断前平均29.9(±26.6)个月患有荨麻疹。在荨麻疹的严重程度、发作频率、腹痛和诊断前症状持续时间方面,两组之间存在统计学上的显著差异。病例组接受幽门螺杆菌感染治疗后,荨麻疹完全痊愈27例(67.5%),部分痊愈13例(32.5%),对照组完全无症状59例(73.8%),未完全痊愈21例(26.3%)。结论:幽门螺杆菌感染可能与CU的发生有关,因此根除幽门螺杆菌作为治疗CU的手段具有重要意义。
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