{"title":"Synthesis, Crystal Structures, and Insulin Enhancement of Vanadium(V) Complexes Derived From 2-Bromo-N’-(2-hydroxybenzylidene)benzohydrazide","authors":"Yubin Sun, Qinglan Xie, Wei Li, Yi Ding, Y. Ye","doi":"10.1080/15533174.2015.1137039","DOIUrl":null,"url":null,"abstract":"Two new mononuclear vanadium(V) complexes with the formula [VOLX] [X = benzohydroxamate for 1, and X = 8-hydroxyquinoline for 2; L = 2-bromo-N’-(2-hydroxybenzylidene)benzohydrazide], have been prepared. The complexes have been characterized by physicochemical methods and single crystal X-ray determination. The V atoms in both complexes are coordinated by the three donor atoms of L, two donor atoms of X, and one oxo group, forming octahedral coordination. Insulin-mimetic tests on C2C12 muscle cells using biovision glucose assay indicates that the complexes significantly stimulated cell glucose utilization with cytotoxicity at 0.10 g L−1.","PeriodicalId":22118,"journal":{"name":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15533174.2015.1137039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Two new mononuclear vanadium(V) complexes with the formula [VOLX] [X = benzohydroxamate for 1, and X = 8-hydroxyquinoline for 2; L = 2-bromo-N’-(2-hydroxybenzylidene)benzohydrazide], have been prepared. The complexes have been characterized by physicochemical methods and single crystal X-ray determination. The V atoms in both complexes are coordinated by the three donor atoms of L, two donor atoms of X, and one oxo group, forming octahedral coordination. Insulin-mimetic tests on C2C12 muscle cells using biovision glucose assay indicates that the complexes significantly stimulated cell glucose utilization with cytotoxicity at 0.10 g L−1.