Synthesis, Crystal Structures, and Insulin Enhancement of Vanadium(V) Complexes Derived From 2-Bromo-N’-(2-hydroxybenzylidene)benzohydrazide

Abstract

Two new mononuclear vanadium(V) complexes with the formula [VOLX] [X = benzohydroxamate for 1, and X = 8-hydroxyquinoline for 2; L = 2-bromo-N’-(2-hydroxybenzylidene)benzohydrazide], have been prepared. The complexes have been characterized by physicochemical methods and single crystal X-ray determination. The V atoms in both complexes are coordinated by the three donor atoms of L, two donor atoms of X, and one oxo group, forming octahedral coordination. Insulin-mimetic tests on C2C12 muscle cells using biovision glucose assay indicates that the complexes significantly stimulated cell glucose utilization with cytotoxicity at 0.10 g L−1.