Action of Three Species of Propionibacteria (P. granulosum, P. acnes, P. avidum) on Experimental Tumor Systems in Mice

Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie Pub Date : 1980-03-01 DOI:10.1016/S0172-5599(80)80078-2

Waldemar Roszkowski , Miroslaw Kobus , Miroslaw Luczak , Hong Lioe Ko , Stanislaw Szmigielski , Bozena Laskowska , Gerhard Pulverer , Janusz Jeljaszewicz

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引用次数: 9

Abstract

The antitumor activity of three differenr species of Propionibacteria (P. granulosum, P. avidum and P. acnes) against murine Sarcoma 180 and Moloney-Sarcoma-Virus-induced tumor (MSV tumor) was investigated.

All three Propionibacteria injected intraperitoneally or intratumorally in multiple doses of 1 mg per mouse appeared to be effective regarding the retardation of growth and the stimulation of regression of Sarcoma 180 in CFW mice. Moreover, the application of Propionibacteria significantly prolonged the survival of Sarcoma-180-bearing mice. No significant differences were found in antitumor effect against Sarcoma 180 between P. granulosum, P. avidum and P. acnes, but in general, intratumoral injections of all three strains were more effective than intraperitoneal applications.

All three strains of Propionibacteria were equally ineffective regarding the retardation of growth and the stimulation of regression of MSV tumors in adult NMRI mice, as assessed after intraperitoneal injections of P. granulosum, P. avidum or P. acnes (1 mg per mouse) 3 days prior to inoculation of virus particles.

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三种丙酸菌(颗粒丙酸菌、痤疮丙酸菌、avidum丙酸菌)对小鼠实验肿瘤系统的作用

研究了3种不同种类丙酸菌(P. granulosum、P. avidum和P. acnes)对小鼠180型肉瘤和moloney -Sarcoma- virus - tumor (MSV tumor)的抗肿瘤活性。在CFW小鼠中，腹腔注射或瘤内注射三种丙酸菌，每只小鼠多剂量注射1毫克，似乎有效地延缓了180肉瘤的生长和刺激其消退。此外，丙酸菌的应用显著延长了肉瘤-180小鼠的存活时间。颗粒假单胞菌、avidum假单胞菌和痤疮假单胞菌对180肉瘤的抗肿瘤作用无显著差异，但总的来说，瘤内注射这三种菌株比腹腔注射更有效。在接种病毒颗粒3天前腹腔注射颗粒P.、avidum P.或痤疮P.(每只小鼠1 mg)后，所有三株丙酸菌对NMRI成年小鼠的MSV肿瘤的生长阻滞和刺激消退都同样无效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie

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