Immunomodulator Activity of Puguntano (Picria fel-terrae Lour.) Extract in White Male Mice By Carbon Clearance Method

Indonesian Journal of Pharmaceutical and Clinical Research Pub Date : 2020-12-31 DOI:10.32734/IDJPCR.V3I2.4306

Rezza Fikrih Utama, Rosidah, Yuandani

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引用次数: 1

Abstract

Poguntano Herb Plants (Picria fel-terrae Lour.) contains flavonoids compounds that have been potentially to developed into immunomodulators. The purpose of this study was to determine the immunomodulatory activity of Poguntano herb extract (Picria fel-terrae Lour.), with the method of carbon clearance. n-hexane extract puguntano herb(ENHHP), extract of ethyl acetate of Poguntano herb (EEAHP), and ethanol extract of puguntano herb(EEHP) Poguntano multistage results in the test of immunomodulatory activity with a method of carbon clearance. Results showed that the EEHP 200 mg/kg BB showed a strong immunostimulation effect, EEAHP 200 mg/kg BB showed strong immunostimulation effect, ENHP 200 mg/kg BB demonstrated strong immunostimulation effect. It is thought that extract N-hexane herb Poguntano (ENHHP), extracts of ethyl herb acetate Poguntano (EEAHP), and herb ethanol extract Poguntano (EEHP) Poguntano herb may increase phagocytosis activity. Extract of ethyl acetate Poguntano herb 200 mg/kg bw (EEAHP) has the best phagocytosis activity with a value of 2.376 which indicates there is a significant difference (P < 0.05) with another treatment group.

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蒲公藤的免疫调节活性碳清除法提取白雄性小鼠

Poguntano草本植物(Picria felterrae Lour.)含有类黄酮化合物，已被开发成潜在的免疫调节剂。本研究采用碳清除法测定蒲甘草叶提取物(Picria felterrae Lour.)的免疫调节活性。采用碳清除法对蒲公英多阶段免疫调节活性进行试验，结果表明:蒲公英多阶段免疫调节活性的试验结果为正己烷提取物(ENHHP)、乙酸乙酯提取物(EEAHP)和乙醇提取物(EEHP)。结果表明，EEHP 200 mg/kg BB具有较强的免疫刺激作用，EEAHP 200 mg/kg BB具有较强的免疫刺激作用，ENHP 200 mg/kg BB具有较强的免疫刺激作用。结果表明，正己烷型药材Poguntano萃取物(ENHHP)、乙酸乙酯型药材Poguntano萃取物(EEAHP)和乙醇型药材Poguntano萃取物(EEHP)均可提高Poguntano的吞噬活性。茯苓乙酸乙酯提取物200 mg/kg bw (EEAHP)的吞噬活性最好，为2.376，与其他处理组差异显著(P < 0.05)。

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Indonesian Journal of Pharmaceutical and Clinical Research

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