Learning and Memory Enhancing Effects of BacoLive andreg; (An Enriched Composition of Bacopa monnieri Extract) in Scopolamine Induced Memory Impaired Mice

Abstract

Objective: The objective of this study was to evaluate the learning and memory enhancement activity of BacoLive® (a composition enriched with bacosides from Bacopa monnieri) in various experimental models i.e., passive shock avoidance test, Y- maze test and novel object recognition test. Methodology: BacoLive® was administered for 7 days at the dose of 100, and 200 mg/kg to mice in passive shock avoidance test, Y-Maze test and in novel object recognition test. Scopolamine (0.5 mg/kg) was used to induce memory (amnesia) loss and piracetam (200 mg/kg) served as reference standard. After 7 days, cognitive and memory scales were measured as per standard test protocols. Results: In the passive shock test for memory, BacoLive ® reduced the latency to reach the shock free zone compared to amnesia induced group. In the Y-maze test, the number of arm entries failed to memorize the new space was decreased with BacoLive ® group compared to amnesia induced group. In the new object recognition test, BacoLIve ® improved the percentage preference for new object recognition compared to amnesia induced group. Conclusion: Based on the present study and findings, BacoLive® demonstrated learning and memory enhancing effects and reversed memory loss effects induced by scopolamine in mice, which suggest its beneficial role in conditions associated with memory and learning dysfunctions. Study indicates that bacopa extract justifies its traditional use in Ayurveda for memory related complications associated with neuro degeneration and stress.