Reduced immune system responsiveness in fibromyalgia - A pilot study

Sophia Björkander , Malin Ernberg , Indre Bileviciute-Ljungar
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引用次数: 3

Abstract

Fibromyalgia is characterized by widespread musculoskeletal and joint pain, stiffness, fatigue, and sleep and mood disorders. However, the involvement of the immune system in the pathways of fibromyalgia is unclear. The aim of this study was to explore the role of the immune system in comparison with healthy controls and in association with clinical symptoms. Thirteen women with fibromyalgia and 14 controls were included. Peripheral blood mononuclear cells were stimulated and analysed by flow cytometry, and interferon gamma (IFN-γ) and interleukins were measured. Among clinical symptoms, the fibromyalgia group showed decreased cold pain threshold. Immunologically, they had a higher percentage of monocytes, a lower percentage of CD19+ B-cells, and lower secretion of IFN-γ after stimulation. Decreased capacity to secrete IFN-γ was significantly correlated with decreased cold pain threshold in the fibromyalgia group. These results confirm the presence of immune aberrations in fibromyalgia, at least partially responsible for the associated pain.

纤维肌痛患者免疫系统反应性降低-一项初步研究
纤维肌痛的特点是广泛的肌肉骨骼和关节疼痛,僵硬,疲劳,睡眠和情绪障碍。然而,免疫系统参与纤维肌痛的途径尚不清楚。本研究的目的是探讨免疫系统的作用,与健康对照,并与临床症状的关系。包括13名患有纤维肌痛的女性和14名对照组。流式细胞术对外周血单个核细胞进行刺激和分析,并测定干扰素γ (IFN-γ)和白细胞介素。临床症状中,纤维肌痛组冷痛阈值降低。免疫方面,刺激后小鼠单核细胞百分比较高,CD19+ b细胞百分比较低,IFN-γ分泌较低。纤维肌痛组IFN-γ分泌能力下降与冷痛阈值降低显著相关。这些结果证实了纤维肌痛中存在免疫异常,至少部分导致了相关的疼痛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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