Edaravone’s Antioxidant Capabilities and its Therapeutic Benefits for Post-Ischemic Stroke: A Mini Review

Abstract

One of the main pathways leading to cell death in ischemic stroke is oxidative stress. Free radical toxicity contributes to an array of cellular damage including inflammation, protein degradation, DNA damage and cellular apoptosis [3]. When combined, these processes all lead to tissue damage and ultimately cell death [3]. Due to a variety of factors, the tolerance to ischemia differs based on collateral circulation pathways, genetic and epigenetic differences [4,5]. Regardless of these individual differences, infractions extend with time ultimately resulting in irreversible injury to a vascular territory.