Magnetic resonance microsystems for life science applications

The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. Pub Date : 2005-06-05 DOI:10.1109/SENSOR.2005.1497493

L. Fan, W. Huang, C. Cheng, P. Chu, H. Hao, C. Hsieh, S. H. Hsu, A. Chin, K. Hsueh, C. Lee, J. Chang, E. Liu, A. Huang, Chen-Fu Chien, A. Yeh, J. Chen, W. Wu, C. Lai

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引用次数: 1

Abstract

Nuclear magnetic (MR) resonance spectroscopy and imaging technique are powerful methods available for determining molecular structures and non-invasive 3D imaging. In the effort of developing a nanoMRI microsystem, the authors have designed, fabricated, assembled and did preliminary characterization of the nanoMRI probe. A multilayer high aspect ratio metal process has been developed for this project. NanoMRI probes are designed through multi-physics finite element 3D analysis, integrated using the high aspect ratio process, assembled, and the RF coils are matched and tuned to a 500MHz system. Due to the large magnetic field gradients and fast switching gradient coils, the high mass-sensitivity and additional orthogonal RF signal channels, special MR pulse sequencies (Lauterbur et al., 1992) can be developed for imaging and molecular structural analysis.

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生命科学应用的磁共振微系统

核磁共振波谱和成像技术是确定分子结构和非侵入性三维成像的有力方法。在开发纳米omri微系统的过程中，作者设计、制作、组装了纳米omri探针，并对其进行了初步表征。为此开发了一种多层高纵横比金属工艺。NanoMRI探针通过多物理场有限元3D分析设计，采用高纵横比工艺集成，组装，RF线圈匹配并调谐到500MHz系统。由于大的磁场梯度和快速开关梯度线圈，高质量灵敏度和额外的正交射频信号通道，特殊的磁共振脉冲序列(Lauterbur等人，1992)可以开发成像和分子结构分析。

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The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.

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