P089 Candidemia: prevalence, species characterization ,and the antibiotic susceptibility profile from a tertiary care hospital in north india

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.1093/mmy/myac072.P089

A. William, R. Kaur, D. Rawat, Pradeep Kumar

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Abstract

Abstract Poster session 1, September 21, 2022, 12:30 PM - 1:30 PM Objectives The aim of this study was to characterize the Candida spp. isolated from blood cultures and determine the antifungal susceptibility pattern of the Candida species prevalent in a tertiary care hospital in North India. Methods This retrospective study was conducted in Department of Microbiology of a tertiary care hospital in North India from April 2020 to March 2022. All blood cultures received in the department during this period were included in the study. Candida species isolated were identified and antifungal susceptibility testing was performed by VITEK as per standard protocol, The susceptibility pattern of 50 isolates was also performed by the broth microdilution method as per Clinical and Laboratory Standards Institute guidelines (CLSI) and the results were compared with VITEK results. Results Out of 21 804 blood cultures received during this period, 177 grew Candida species. Therefore, the overall prevalence of Candida species was 0.81% in our study. The incidence of bloodstream infection caused by non-albicans Candida species (80%) was higher than C. albicans (20%). Among NAC species, C. tropicalis (45%) was the most common, followed by C. pelliculosa (15%). Candidemia was predominantly observed in ICU patients. Resistance was seen in 14.1% isolates to voriconazole and fluconazole, 4.2% to flucytosine and 3.9% to caspofungin and amphotericin-B. No resistance was seen to micafungin. A total of 15% of the isolates were resistant to more than one drug. Conclusion There was a predominance of non-albicans Candida over C. albicans. Maximum resistance was seen to voriconazole followed by fluconazole. Continuous surveillance is necessary to follow trends and monitor changes in epidemiological and resistance patterns in different geographical regions, especially in critically ill patients.

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念珠菌:印度北部一家三级医院的流行、物种特征和抗生素敏感性

摘要:海报会议1,2022年9月21日，下午12:30 - 1:30目的本研究的目的是表征从血液培养中分离的念珠菌属，并确定在印度北部三级保健医院流行的念珠菌种的抗真菌药敏模式。方法于2020年4月至2022年3月在印度北部某三级医院微生物科进行回顾性研究。在此期间，该部门收到的所有血液培养都包括在研究中。对分离的念珠菌菌种进行鉴定，按照标准方案进行VITEK药敏试验，并按照临床与实验室标准协会指南(CLSI)采用肉汤微量稀释法对50株念珠菌进行药敏分析，并与VITEK结果进行比较。结果21 804例血培养中，有177例培养出念珠菌。因此，在我们的研究中，念珠菌的总体患病率为0.81%。非白色念珠菌引起的血流感染发生率(80%)高于白色念珠菌(20%)。在NAC种类中，最常见的是热带c(45%)，其次是薄皮c(15%)。念珠菌主要见于ICU患者。对伏立康唑和氟康唑耐药14.1%，对氟胞嘧啶耐药4.2%，对caspofungin和两性霉素- b耐药3.9%。没有发现对米卡芬的抵抗。共有15%的分离株对一种以上药物耐药。结论非白色念珠菌优于白色念珠菌。伏立康唑耐药性最大，氟康唑次之。必须进行持续监测，以跟踪趋势并监测不同地理区域，特别是危重病人的流行病学和耐药性模式的变化。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.