Ionic messengers in development and cancer.

M. Moreau, C. Leclerc
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引用次数: 1

Abstract

The idea that electrical fields can influence the development of an organism is not new. Electrical fields in cells are mainly due to the presence of channels which are permeable and selective for different ions and transporters. Modulation of their activities can affect cell cycle properties, proliferation and differentiation.Electrical fields are important for embryonic patterning, regeneration and tumour development. Membrane potential is a permanent signal which allows communication between cells, tissues and organs and has to be considered to have the same importance as biochemical signals. The activity of ion channels and pumps which maintain the electrical fields can now be dissected and visualized with new tools involving fluorescent reporters.Despite the fact that our understanding, at the molecular level, of the role of bioelectric signaling pathways, ion currents, voltage and pH gradients in developmental biology and tumor progression is increasing, therapeutic applications of this knowledge still appears to be far away. For the moment, research priorities seem to be on establishing the links between biochemical events, genetic regulation, and network interactions.
发育和癌症中的离子信使。
电场可以影响有机体发育的想法并不新鲜。细胞中的电场主要是由于通道的存在,这些通道对不同的离子和转运体具有渗透性和选择性。调节它们的活性可以影响细胞周期特性、增殖和分化。电场对胚胎的形成、再生和肿瘤的发展都很重要。膜电位是一种永久的信号,它允许细胞、组织和器官之间的交流,并且必须被认为与生化信号具有同样的重要性。维持电场的离子通道和泵的活性现在可以用涉及荧光报告的新工具进行解剖和可视化。尽管我们在分子水平上对生物电信号通路、离子电流、电压和pH梯度在发育生物学和肿瘤进展中的作用的理解正在增加,但这些知识的治疗应用似乎仍然很遥远。目前,研究的重点似乎是建立生化事件、基因调控和网络相互作用之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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