Validation of Bench Durability of Bioprosthetic Heart Valves

S. Lieber
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Abstract

The number of heart valve replacements is increasing in the United States and worldwide due to aging of the population. This situation requires bioprosthetic heart valves with higher durability to reduce the rate of reoperation and the need for anticoagulation. However, introducing any improvement in the design of a heart valve requires ten years of validation in a clinical setup. A validated in-vitro fatigue testing system would significantly accelerate these innovations. The main objective of the proposed research is to: • Determine the dynamics of flow patterns and stresses in the vicinity of a bioprosthetic heart valve under pulsatile flow conditions. • Use the flow pattern information to validate an in-vitro fatigue testing system under physiological and accelerated conditions.
生物人工心脏瓣膜台架耐久性的验证
由于人口老龄化,在美国和世界范围内,心脏瓣膜置换术的数量正在增加。这种情况需要具有更高耐久性的生物人工心脏瓣膜,以减少再手术率和抗凝的需要。然而,心脏瓣膜设计的任何改进都需要10年的临床验证。一个经过验证的体外疲劳测试系统将大大加速这些创新。拟议研究的主要目的是:•确定脉动流条件下生物假体心脏瓣膜附近的流动模式和应力的动态。•在生理和加速条件下,使用流型信息验证体外疲劳测试系统。
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