Development of Gastroretentive Floating Tablets Quetiapine Fumarate

Abstract

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/ by/4.0) ABSTRACT The idea of the study is to prepare and characterize a sustain release floating tablets of Quetiapine Fumarate for Schizophrenia. Materials which are used in making of effervescent Tablets are hydroxy-methylcellulose HPMC. For the buoyancy sodium bicarbonate is used. Initially for the selection of formulation Definitive screening design is used which allows to study the effect of large number of factors in relatively small experiment. The optimized formulation is tested for release rate, buoyancy, hardness, thickness, floating time, swelling study and release rate. These studies shows that optimized tablet remains in stomach for 24h and shows release rate of 91% which is very desirable.