{"title":"Innovative Observation of MDA-MB-231 Cell Vitality in Mice Upon 266-nm Laser Irradiation","authors":"Ray-Ling Hsiao, Ying-chun Chen, Chiang-Yun Chen, Yu-Wei Lin, Chung-Yi Wu","doi":"10.26502/jbb.2642-91280042","DOIUrl":null,"url":null,"abstract":"In this innovative experiment, MDA-MB-231 cells were irradiated with a 266-nm laser for 5s, and then injected into NOD/SCID mice. The survival rate of the experimental mice was significantly reduced compared to that of the control mice (p=0.029), which also indicated the vitality of the experimental cells in vivo. The enhancement effect of a 266-nm laser on cells in xenotransplantation after 5 s of exposure was studied for the first time in this study. The findings of this study provide potential for future live cell therapies.","PeriodicalId":15066,"journal":{"name":"Journal of Biotechnology and Biomedicine","volume":"96 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biotechnology and Biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26502/jbb.2642-91280042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In this innovative experiment, MDA-MB-231 cells were irradiated with a 266-nm laser for 5s, and then injected into NOD/SCID mice. The survival rate of the experimental mice was significantly reduced compared to that of the control mice (p=0.029), which also indicated the vitality of the experimental cells in vivo. The enhancement effect of a 266-nm laser on cells in xenotransplantation after 5 s of exposure was studied for the first time in this study. The findings of this study provide potential for future live cell therapies.