mRNA COVID-19 vaccine: A future hope for cancer treatment

A. Yadav, Suman Gnawali, S. Mandal, Gyaneswhor Shrestha, G. Yuan
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引用次数: 1

Abstract

Background: mRNA vaccines have a strong potential for a possible cancer therapy platform. They express tumor antigens in antigen-presenting cells (APCs) after immunization, facilitating innate/adaptive immune stimulation. Because of its high effectiveness, safe administration, rapid development potential, and cost-efficient manufacturing, the mRNA cancer vaccine surpasses other traditional vaccination platforms. Conclusion: Careful evaluation of promising mRNA vaccines to supervise as carriers of lipids for cancer patients needs to be done. In addition, a possible revaluation for optimal protection is required. However, the extent to which solid tumours might take a significant part of the vaccine doses is still unknown. 
mRNA COVID-19疫苗:癌症治疗的未来希望
背景:mRNA疫苗具有成为癌症治疗平台的巨大潜力。它们在免疫后在抗原呈递细胞(APCs)中表达肿瘤抗原,促进先天/适应性免疫刺激。由于其高效、安全的给药、快速的开发潜力和成本效益的制造,mRNA癌症疫苗超越了其他传统的疫苗接种平台。结论:需要仔细评估mRNA疫苗作为肿瘤患者脂质载体的应用前景。此外,为了获得最佳保护,可能需要重估汇率。然而,实体肿瘤在多大程度上可能占用疫苗剂量的很大一部分仍是未知的。
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