Alkaline hydrogen peroxide solutions with expectorant, pyolytic, mucolytic, haemolytic, oxygen-releasing and decolorising effects

Abstract

Abstract. It was shown that the effect of local action of hydrogen peroxide solution on such dense biological masses as pus, mucus, sputum and blood clots depends not only on the concentration of the main ingredient, but also on the alkalinity of the solution as well as on the temperature of the interaction media. In particular, an increase in solution temperature from +24 - +26 to +45 - +55 C and its alkalinity from pH 7.0 to pH 8.4 - 8.5 increases the pyolytic, mucolytic, hemolytic, bleaching and oxygen-releasing activity of hydrogen peroxide solutions. The indicated level of hyperthermia is provided by simple physical heating of the solution, and the indicated level of alkalinity is provided by introducing sodium bicarbonate into it. It has been found out that hyperthermia according to the laws of physics reduces viscosity of biological masses, increases their fluidity, permeability to the antiseptic solution, miscibility and solubility in it as well as increases the rate of chemical, physico-chemical and biochemical processes according to Arrhenius law. In particular, increasing the temperature of interacting media accelerates the process of alkaline saponification of proteins and protein-lipid complexes that form the basis of colloidal biological masses. In addition, hyperthermia accelerates and strengthens the process of enzymatic decomposition of hydrogen peroxide into water and oxygen gas, which takes place under the action of the enzyme catalase, which is always present in most biological masses. At the same time, the released molecular oxygen forms gas bubbles, which simulate the process of cold boiling and due to this "explode" biological masses, turning them into a fluffy white foam. The fact is that oxygen in an alkaline environment oxidizes biological pigments, including hemoglobin and its metabolites of different colors, and discolors them.