High Expansion Auxetic Skin Graft Simulants for Severe Burn Injury Mitigation

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-03-11 DOI:10.3390/ebj4010011

Vivek Gupta, Gurpreet Singh, A. Chanda

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引用次数: 1

Abstract

Burn injuries are commonly treated with split-thickness skin grafting. However, low expansions offered by spilt-thickness skin grafting inhibit the treatment of large and severe burn injuries when limited donor skin is available. To overcome this gap, in this work, it was attempted to study the expansion potential of skin grafts with novel auxetic incisions with rotating rectangle (RR), honeycomb (HC), alternating slit (AS), H-shaped (HS), Y-shaped (YS), and I-shaped (IS) unit cells, through development of skin graft simulants. Clinically relevant biaxial load testing was conducted to estimate the stress–strain response, void area, and meshing ratio. Moreover, hyperelastic constitutive models were employed to characterize the non-linear biomechanical behavior of the skin graft simulants. The maximum void area increase was observed in the HS skin graft simulant, indicating low skin cover. Overall, the IS auxetic skin graft design exhibited meshing ratio higher than traditional grafts (>3:1), low void area and stresses, which can be beneficial for large skin cover and burn wound healing. With further optimization and clinical tests, the auxetic skin graft designs may find a place with the graft manufacturers for fabrication of grafts with better surgical outcomes for severe burn injuries.

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缓解严重烧伤的高膨胀辅助皮肤移植模拟剂

烧伤的治疗通常采用裂皮植皮术。然而，当供体皮肤有限时，厚皮移植提供的低扩张会抑制大面积严重烧伤的治疗。为了克服这一差距，本研究试图通过开发皮肤移植模拟物，研究具有旋转矩形(RR)、蜂窝(HC)、交替狭缝(AS)、h形(HS)、y形(YS)和i形(IS)单位细胞的新型补体切口的皮肤移植物的扩张潜力。进行临床相关的双轴载荷试验以估计应力-应变响应、空洞面积和啮合比。此外，采用超弹性本构模型来表征模拟皮肤移植的非线性生物力学行为。在HS皮肤移植模拟物中观察到最大空隙面积增加，表明皮肤覆盖度低。总体而言，IS仿生植皮设计具有比传统植皮更高的啮合比(>3:1)、更小的空隙面积和应力，有利于大面积皮肤覆盖和烧伤创面愈合。通过进一步的优化和临床试验，这种补体植皮设计可能会在植皮制造商那里找到一席之地，用于制造具有更好手术效果的严重烧伤植皮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.