A case of de novo seronegative inflammatory oligoarthritis associated with COVID-19 infection

Clinical Immunology Communications Pub Date : 2022-12-01 DOI:10.1016/j.clicom.2022.10.001

Lily H. Sung MD , Natalya Surmachevska DO , Jose E. Rubio MD

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引用次数: 1

Abstract

Infection with SARS-CoV-2 (COVID-19) virus is characterized by an acute respiratory viral illness, often accompanied by extrapulmonary manifestations. Musculoskeletal symptoms such as myalgias and arthralgias are observed in 60 – 70% of cases. Inflammatory arthritis associated with SARS-CoV-2 infection has been reported in the literature, however, nearly all such cases describe a post-viral or reactive phenomenon occurring a few weeks following the infection. We report a unique case of de novo arthritis at the onset of a confirmed COVID-19 infection in a 55-year-old woman. Magnetic resonance imaging demonstrated synovial enhancement consistent with synovitis. Her disease was deemed refractory after failing several immunosuppressive agents. Lastly, we compare our patient's clinical presentation with two other similar cases to understand the natural history of this emerging syndrome.

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新发血清阴性炎性少关节炎合并COVID-19感染1例

SARS-CoV-2 (COVID-19)病毒感染的特征是急性呼吸道病毒性疾病，通常伴有肺外表现。肌肉骨骼症状，如肌痛和关节痛在60 - 70%的病例中观察到。文献中已经报道了与SARS-CoV-2感染相关的炎症性关节炎，然而，几乎所有此类病例都描述了感染后几周发生的病毒后或反应性现象。我们报告了一例独特的新发关节炎在确诊的COVID-19感染发病的55岁女性。磁共振成像显示滑膜增强与滑膜炎一致。她的疾病在几种免疫抑制剂无效后被认为是难治性的。最后，我们将患者的临床表现与其他两个类似病例进行比较，以了解这种新出现综合征的自然历史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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