Antimicrobial and regulatory effects of thiazolo pyridine derivatives

Abstract

a synthesized compound of find the possible mechanisms of their effects on the activity of the NO-synthase system of lymphocytes, important regulators of adaptive possibilities of an of antibacterial and antifungal activity against the isolates of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Pseudomonas aureginosa, Bacillus subtilis, Escherichia coli, Proteus vulgaris and Candida albicans by agar diffusion and serial dilutions, about 50 original thiazolopyridine were studied. Among these derivatives, the compound of N-[2-(5,7-dimethyl-2-oxo-thiazolo [4,5-b]-pyridin-3-yl)-acetyl]-hydrazide of acetate acid was detected in the study. This compound showed high antimicrobial effect in comparison with amoxicillin/clavulanate using different test cultures of microorganisms. To determine the regulatory effect of N-[2-(5,7-dimethyl-2-oxo-thiazolo[4,5-b] pyridin-3-yl)-acetyl]-hydrazide acetic acid on the NO-Synthase activity peripheral