The Effect of Chronic Swimming Exercise and Vitamin E Supplementation on Bone Element Metabolism in Epileptic Rats.

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2023-12-07 eCollection Date: 2024-01-01 DOI:10.29399/npa.28495

Saltuk Buğra Baltacı, Erkut Tutkun, Mustafa Ayyıldız, Erdal Ağar, Gökhan Arslan, Rasim Moğulkoç, Abdülkerim Kasım Baltacı

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引用次数: 0

Abstract

Introduction: This study aimed to investigate the effects of chronic swimming exercise and vitamin E administration on elemental levels in the bone tissue of epileptic rats.

Methods: Forty-eight rats were divided into six groups: Control, Swimming, Swimming + vitamin E, Swimming + Epilepsy, Swimming + Epilepsy + vitamin E, and Epilepsy. Vitamin E was administered to the animals chronically by gavage at a dose of 500 mg/kg every other day for 3 months. Epileptiform activity was induced with penicillin in animals 24 hours after the last vitamin E intake. The exercise program consisted of daily 30-minute swimming sessions. At the end of the treatment period, the levels of calcium, chromium, copper, iron, magnesium, manganese, lead, and zinc (µg/gram tissue) in bone tissue samples were measured using an atomic emission device.

Results: The results showed that all epileptic groups had significantly lower bone chromium levels compared to the control groups (p<0.05). The epileptic, and epileptic swimming groups had the lowest levels of bone calcium, magnesium, and zinc (p<0.05). Vitamin E administration resulted in a significant increase in bone calcium, magnesium, and zinc levels in the epileptic swimming group with vitamin E compared to the epileptic and epileptic swimming groups. (p<0.05).

Conclusion: The findings of the study show that the administration of vitamin E improves calcium, magnesium, and zinc metabolism in the deteriorated bone tissue of the epileptic rat model.

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慢性游泳运动和维生素 E 补充剂对癫痫大鼠骨元素代谢的影响

引言本研究旨在探讨长期游泳运动和服用维生素 E 对癫痫大鼠骨组织中元素水平的影响：方法：将 48 只大鼠分为 6 组：对照组、游泳组、游泳 + 维生素 E 组、游泳 + 癫痫组、游泳 + 癫痫 + 维生素 E 组和癫痫组。给动物长期灌胃维生素 E，剂量为 500 毫克/千克，每隔一天灌胃一次，连续灌胃 3 个月。在最后一次摄入维生素 E 24 小时后，用青霉素诱导动物出现癫痫样活动。运动项目包括每天30分钟的游泳训练。治疗结束后，使用原子发射装置测量骨组织样本中钙、铬、铜、铁、镁、锰、铅和锌（微克/克组织）的含量：结果：结果显示，与对照组相比，所有癫痫组的骨铬含量都明显较低（p）：研究结果表明，服用维生素 E 可改善癫痫模型大鼠骨组织中钙、镁和锌的代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.