Oncolytic effect of Newcastle disease virus (NDV) strain AF2240 and V4-UPM on hypoxic and normoxic osteosarcoma cells

IF 0.4 Q4 MICROBIOLOGY

Malaysian Journal of Microbiology Pub Date : 2023-08-01 DOI:10.21161/mjm.230191

Nurneqman Nashreq Kosni, Noraini Abd-Aziz, Abdul Rahman Omar, Saila Ismail, Suet Lin

引用次数: 0

Abstract

Aims: Hypoxia is believed to be one of the key components contributing to the clinical resistance of cancer therapies. Alternative strategies are under investigation to overcome this resistance and the oncolytic virus stands amongst the others. Newcastle disease virus (NDV) has been demonstrated to possess oncolytic activity against cancer cells. The present study investigated the effects of oncolytic NDV strain AF2240 and V4-UPM on osteosarcoma cells (Saos-2) under normoxic and hypoxic conditions

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新城疫病毒(NDV) AF2240株和V4-UPM对缺氧和常氧骨肉瘤细胞的溶瘤作用

目的:缺氧被认为是癌症治疗临床耐药的关键因素之一。目前正在研究克服这种耐药性的替代策略，溶瘤病毒是其中之一。新城疫病毒(NDV)已被证实对癌细胞具有溶瘤活性。本研究研究了溶瘤性NDV菌株AF2240和V4-UPM在常氧和缺氧条件下对骨肉瘤细胞(Saos-2)的影响

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Microbiology MICROBIOLOGY-

CiteScore

0.70

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： The Malaysian Journal of Microbiology (MJM) publishes high quality microbiology research related to the tropics. These include infectious diseases and antimicrobials. In addition, the journal also publishes research works on the application of microbes for the betterment of human society and the environment. The journal welcomes papers on isolation, identification, characterization and application of microbes and microbial products. The MJM is published under the auspices of the Malaysian Society for Microbiology. It serves as a forum for scientific communication among scientists and academics who deal with microbes and microbial products. The journal publishes research articles, short communications and review articles on various novel aspects of microbiology, which include topics related to medical, pharmaceutical, food, agricultural, industry, plant pathology, biotechnology, microbial genetics, environment, soil, water and biodeterioration. The journal aspires to emphasize the important roles played by microbes in our daily life.