Antinflammatory Activity Of A New Pyrazolon Drug

Abstract

Using carrageenan-induced paw inflammation model in rats, the anti-inflammatory effects of 4-acetyl – 1 phenyl 1-3 methyl 1 pyrazolone (HAP) were investigated and compared with those of standard anti-inflammatory agents viz indomethacin, HTFP (4triflouroacetyl-1 phenyl-3 methyl pyrazolone) and hydrocortisone. Rats were intraperitoneally administered different doses of HAP, HTFP, indomethacin and hydrocortisone and one hour thereafter, inflammation was induced by injecting carrageenan into the left foot. The right foot received saline. Five rats received carrageenan and saline only. Both the left and right feet were measured hourly for inflammatory response for four (4) hours. HAP, HTFP reduced the inflammatory response by 80% whereas hydrocortisone and indomethacin reduced the inflammatory response by 70% and 84% respectively. These results suggest that HAP, a new pyrazolon derivative may possess anti-inflammatory activity comparable to those of standard anti-inflammatory agents.