SOX2OT, a long non-coding RNA involved in autophagy regulation

Abstract

Human SOX2OT, located in chromosome 3q26.3 encodes for a nonprotein coding long RNA with different alternative splice variants (1). It was discovered as a gene associated with eye developmental disorders including microphthalmia and anophthalmia (2). The function of SOX2OT has been under investigation since its discovery. It has been shown that SOX2OT can regulate the embryonic stem cell in vertebrate (3) and also it has higher expression level in different tumor types taking role in pathogenesis of cancers(4). Article Type: Letter to Editor