Diagnostics of lesions of parenchymatic organs in COVID-19 with the application of digital software processing of computer tomography images

М. Lynnyk, І. Liskina, М. Gumeniuk, V. Іgnatieva, G. Gumeniuk, V. Svyatnenko, І.О. Panashchuk, V. Ivashchenko
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引用次数: 2

Abstract

BACKGROUND. In the third wave of the pandemic, the coronavirus disease 2019 (COVID-19) was more aggressive. The available information on the pathogenesis of respiratory failure was supplemented with new data. Up-date information about the respiratory failure pathogenesis was acquired. It has been shown that the SARS-CoV-2 virus leads to disappearance of white pulp cells in the spleen. In this tissue immune cells mature and differentiate, among others T- and B-lymphocytes, which are responsible for premunition. The study of the structure and function of the spleen has become even more urgent. Some authors note a change in the size of the spleen during ultrasonography and chest computed tomography (CT), which correlate with indicators of the pneumonia“s severity. The study of the structure and function of the spleen has become even more urgent. OBJECTIVE. To study is to evaluate changes in the structure of solid organs (lungs, liver and spleen) in patients with a complicated community-acquired viral pneumonia COVID-19 by means of software digital processing of CT scan data and their comparison with pathomorphological changes. MATERIALS AND METHODS. The analysis of CT data in patients with a complicated community-acquired viral pneumonia COVID-19, who were treated at the SI “National institute of phthisiology and pulmonology named. F.G. Yanovsky of the NAMS of Ukraine”. CT WGC was performed on an Aquilion TSX-101A «Tochiba» scanner (Japan), followed by digital software processing of CT images using the Dragonfly software. Histological preparations were obtained as a result of traditional alcoholic histological tracing of tissue samples, embedded in paraffin blocks. To obtain micrographs, an Olympus BX51 microscope was used with an Olympus DP73 digital camera and a CellSens computer program for image processing. RESULTS AND DISCUSSION. The obtained results of digital software processing of CT images clearly correlate with autopsy histological examination of tissues of the same solid organs. Changes in the structure of the spleen occur earlier than in other solid organs, which gives reason to use these changes for diagnostic purposes. Digital processing of CT images of the spleen allows determining the severity of the disease, predicting its further course and evaluating the effectiveness of treatment. CONCLUSIONS. In patients with a complicated viral (COVID-19) community-acquired pneumonia changes (which can be determined by digital software processing of CT data) in the structure of solid organs, especially in lungs and spleen, were observed and they correlate with pathomorphological changes.
计算机断层成像数字软件处理在新冠肺炎实质器官病变诊断中的应用
背景。在第三波大流行中,2019年冠状病毒病(COVID-19)更具攻击性。有关呼吸衰竭发病机制的现有资料得到了新的补充。获得了呼吸衰竭发病机制的最新信息。研究表明,SARS-CoV-2病毒会导致脾脏白髓细胞消失。在这个组织中,免疫细胞成熟并分化,其中包括负责免疫的T淋巴细胞和b淋巴细胞。脾的结构和功能的研究已变得更加迫切。一些作者注意到在超声检查和胸部计算机断层扫描(CT)中脾脏大小的变化,这与肺炎严重程度的指标相关。脾的结构和功能的研究已变得更加迫切。目标。本研究是通过对CT扫描数据进行软件数字化处理,并与病理形态学变化进行比较,评价复杂社区获得性病毒性肺炎COVID-19患者实体脏器(肺、肝、脾)结构的变化。材料和方法。在SI“国家细菌学与肺病研究所”接受治疗的复杂社区获得性病毒性肺炎COVID-19患者的CT资料分析。乌克兰海军的f·g·扬诺夫斯基”。CT WGC在Aquilion TSX-101A«Tochiba»扫描仪(日本)上进行,然后使用Dragonfly软件对CT图像进行数字软件处理。组织制备是通过对组织样品进行传统的酒精组织示踪,包埋在石蜡块中获得的。显微镜使用奥林巴斯BX51显微镜,配合奥林巴斯DP73数码相机和CellSens计算机程序进行图像处理。结果和讨论。CT图像的数字软件处理结果与同一实体器官组织的尸检组织学检查结果明显相关。脾脏结构的变化比其他实体器官发生得早,这就有理由使用这些变化来诊断。脾脏CT图像的数字处理可以确定疾病的严重程度,预测其进一步的进程并评估治疗的有效性。结论。在合并病毒性肺炎(COVID-19)的社区获得性肺炎患者中,观察到实体脏器,特别是肺和脾脏的结构变化(可通过CT数据的数字软件处理确定),并与病理形态学改变相关。
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