Mohammed Ali Eshra , Laila Ahmed Rashed , Rania Farag A. Eltelbany , Heba Omar , Asmaa Mohammed ShamsEldeen
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引用次数: 2
Abstract
Background
continuous consumption of high-fat diet (HFD) during pregnancy and lactation could alter developmental complexity of higher brain functions and enhance appearance of social withdrawal and anxiety among offsprings. On the contrary, omega-3 fatty acids with its multi-neuro-protective effects could limit oxidative stress production and complications. We aimed to investigate the impact of HFD intake before and during pregnancy till weaning versus prenatal exposure to valproate (as a model of autism) on behavior and brain neurochemistry as well as the possible therapeutic rational of omega-3 intake.
Material and methods
After confirmation of G0 day of pregnancy, thirty Sprague–Dawley female rats were divided into: control group fed normal chow (10 kcal% from fat), group II (HFD) mothers supplied with diet of 60 kcal% from fat and group III (HFD-Omega) supplied with 60% HFD enriched with omega-3, group IV (Valp) pregnant females received sodium valproate once i.p, and group V (Valp-Omega) rats received valproate once i.p and diet enriched with omega-3. From day 7 till end of the study, offsprings were subjected to growth, neurodevelopmental assessment and behavioral tests using elevated plus maze and social interaction in open field. Levels of serotonin, GABA, neuropeptide Y, IL-6 and relative gene expression of syntaxin1A and FoxO1 gene were measured.
Results
Offsprings born to HFD and Valp-groups demonstrated growth retardation, social withdrawal together with disturbed levels of measured neurotransmitter that were improved in HFD group supplied with omega-3.
Conclusion
Omega-3 exhibited to be potential modulator of behavioral changes and autistic-like features induced by HFD.
期刊介绍：
Neurology, Psychiatry & Brain Research publishes original papers and reviews in
biological psychiatry,
brain research,
neurology,
neuropsychiatry,
neuropsychoimmunology,
psychopathology,
psychotherapy.
The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version.
Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.
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