Optimization of Cyclocarya paliurus Polysaccharide Tablets by Response Surface Method Study on Prescription Process

Abstract

Objective: To optimize the prescription technology of Cyclocarya paliurus polysaccharide tablets. Methods: Cyclocarya paliurus polysaccharide powder was used as raw material and granulated by wet method. On the basis of single factor test, the ratio of main drug to filler, binder concentration and disintegrating agent dosage were taken as the influencing factors, and the comprehensive score of tablet appearance, friability and disintegrating time was taken as the evaluation index. Entropy weight method combined with Box-Behnken response surface method was used to screen the optimal process. Results: The optimal formulation of Cyclocarya paliurus polysaccharide tablet was the ratio of main drug to filler 1:1.179, adhesive concentration 8.879% and disintegrating agent addition 6.719%. Under these conditions, the comprehensive score of Cyclocarya paliurus polysaccharide tablets was 17.163. Conclusion: The theoretical values obtained by process optimization are consistent with the predicted values of the model. The prescription technology is stable and feasible, and the shape appearance, fragility, disintegration time and other indicators met the corresponding quality requirements of the tablets.