The effects of Ginkgo biloba on nephrotoxicity induced by cisplatin-based chemotherapy protocols in rats

IUFS Journal of Biology Pub Date : 2012-12-25 DOI:10.18478/IUFSJB.02974

B. Okuyan, F. Izzettin, Özlem Bingöl-Ozakpinar, P. Turan, Z. Ozdemir, M. Sancar, Z. Cirakli, P. Clark, F. Ercan

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引用次数: 7

Abstract

The study was aimed at investigating the possible renoprotective effects of Ginkgo biloba on nephrotoxicity induced by cisplatin w/wo other antineoplastic agents (etoposide and gemcitabine) in rats. The animals were randomly divided into eight groups each consisting of six rats. Serum blood urea nitrogen (BUN) and creatinine values at baseline and after drug administration, kidney malondialdehyde (MDA), glutathione (GSH) levels, and myeloperoxidase activity (MPO) were measured, and a histopathologic examination of kidney tissues was carried out. Ginkgo biloba extract significantly decreased the serum creatinine and kidney MDA levels, which had increased as a result of cisplatin administration and also improved the depletion of kidney GSH levels in cisplatin administered rats (p<0.05). These results were confirmed by histopathologic observations of the kidney tissues. According to the results of the present study, the potential interactions between the renoprotective agents and the cisplatin-based chemotherapeutic regimens must be considered. Keywords: Cisplatin- induced nephrotoxicity, Etoposide, Gemcitabine, Ginkgo biloba,

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银杏叶对大鼠顺铂化疗所致肾毒性的影响

本研究旨在探讨银杏叶对顺铂联合其他两种抗肿瘤药物(依托泊苷和吉西他滨)所致大鼠肾毒性的可能保护作用。这些动物被随机分为8组，每组6只大鼠。测定基线和给药后血清尿素氮(BUN)和肌酐值，肾脏丙二醛(MDA)、谷胱甘肽(GSH)水平和髓过氧化物酶活性(MPO)，并对肾脏组织进行组织病理学检查。银杏叶提取物显著降低大鼠血清肌酐和肾脏丙二醛水平(顺铂给药后血清肌酐和肾脏丙二醛水平升高)，改善顺铂给药大鼠肾脏GSH水平的消耗(p<0.05)。肾组织病理观察证实了上述结果。根据目前的研究结果，必须考虑到肾保护剂与以顺铂为基础的化疗方案之间的潜在相互作用。关键词:顺铂致肾毒性依托泊苷吉西他滨银杏叶

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IUFS Journal of Biology

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