Vestibular and balance dysfunction in children with congenital CMV: a systematic review.

IF 3.6 1区 心理学 Q1 PSYCHOLOGY, SOCIAL
Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler
{"title":"Vestibular and balance dysfunction in children with congenital CMV: a systematic review.","authors":"Annalie Shears, Georgina Yan, Harriet Mortimer, Elizabeth Cross, Shari Sapuan, Seilesh Kadambari, Suzanne Luck, Paul T Heath, Simone Walter, Katy J Fidler","doi":"10.1136/archdischild-2021-323380","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.</p><p><strong>Design: </strong>MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.</p><p><strong>Patients: </strong>Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture).</p><p><strong>Intervention: </strong>Studies of vestibular function and/or balance assessments.</p><p><strong>Main outcome measures: </strong>Vestibular function and balance.</p><p><strong>Results: </strong>1371 studies were identified, and subsequently 16 observational studies were eligible for analysis, leading to an overall cohort of 600 children with cCMV. All studies were of low/moderate quality. In 12/16 studies, vestibular function tests were performed. 10/12 reported vestibular dysfunction in ≥40% of children with cCMV. Three studies compared outcomes for children with symptomatic or asymptomatic cCMV at birth; vestibular dysfunction was more frequently reported in children with symptomatic (22%-60%), than asymptomatic cCMV (0%-12.5%). Two studies found that vestibular function deteriorated over time: one in children (mean age 7.2 months) over 10 months and the other (mean age 34.7 months) over 26 months.</p><p><strong>Conclusions: </strong>Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case-controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions.</p><p><strong>Prospero registration: </strong>CRD42019131656.</p>","PeriodicalId":51376,"journal":{"name":"European Journal of Personality","volume":"7 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606507/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Personality","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/archdischild-2021-323380","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, SOCIAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.

Design: MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.

Patients: Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture).

Intervention: Studies of vestibular function and/or balance assessments.

Main outcome measures: Vestibular function and balance.

Results: 1371 studies were identified, and subsequently 16 observational studies were eligible for analysis, leading to an overall cohort of 600 children with cCMV. All studies were of low/moderate quality. In 12/16 studies, vestibular function tests were performed. 10/12 reported vestibular dysfunction in ≥40% of children with cCMV. Three studies compared outcomes for children with symptomatic or asymptomatic cCMV at birth; vestibular dysfunction was more frequently reported in children with symptomatic (22%-60%), than asymptomatic cCMV (0%-12.5%). Two studies found that vestibular function deteriorated over time: one in children (mean age 7.2 months) over 10 months and the other (mean age 34.7 months) over 26 months.

Conclusions: Vestibular dysfunction is found in children with symptomatic and asymptomatic cCMV and in those with and without hearing loss. Audiovestibular assessments should be performed as part of neurodevelopmental follow-up in children with cCMV. Case-controlled longitudinal studies are required to more precisely characterise vestibular dysfunction and help determine the efficacy of early supportive interventions.

Prospero registration: CRD42019131656.

先天性巨细胞病毒感染儿童的前庭和平衡功能障碍:系统综述。
目的:本系统综述评估了先天性巨细胞病毒(cCMV)患儿的前庭和平衡功能障碍:本系统综述评估先天性巨细胞病毒(cCMV)患儿的前庭和平衡功能障碍,为临床实践提出建议,并为未来的研究重点提供信息:从开始到 2021 年 3 月 20 日检索了 MEDLINE、Embase、EMCARE、BMJ Best Practice、Cochrane Library、DynaMed Plus 和 UpToDate,并根据加强流行病学观察性研究报告(STROBE)标准进行了分级:患者:出生后 3 周内通过血液、唾液和/或尿液(使用 PCR 或培养)确诊为 cCMV 的儿童:前庭功能和/或平衡评估研究:主要结果测量:前庭功能和平衡能力:结果:共确定了 1371 项研究,其中 16 项观察性研究符合分析条件,因此共有 600 名儿童患有 cCMV。所有研究均为低/中等质量。其中 12/16 项研究进行了前庭功能测试。10/12项研究报告称,≥40%的cCMV患儿存在前庭功能障碍。三项研究比较了出生时有症状或无症状 cCMV 患儿的预后;有症状(22%-60%)和无症状(0%-12.5%)cCMV 患儿的前庭功能障碍发生率更高。两项研究发现,前庭功能会随着时间的推移而退化:一项研究发现,患儿(平均年龄为 7.2 个月)的前庭功能会在 10 个月内退化,另一项研究发现,患儿(平均年龄为 34.7 个月)的前庭功能会在 26 个月内退化:结论:有症状和无症状的 cCMV 患儿、有听力损失和无听力损失的患儿均存在前庭功能障碍。听觉前庭评估应作为 cCMV 患儿神经发育随访的一部分。需要进行病例对照纵向研究,以更准确地确定前庭功能障碍的特征,并帮助确定早期支持性干预措施的疗效:CRD42019131656。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
European Journal of Personality
European Journal of Personality PSYCHOLOGY, SOCIAL-
CiteScore
11.90
自引率
8.50%
发文量
48
期刊介绍: It is intended that the journal reflects all areas of current personality psychology. The Journal emphasizes (1) human individuality as manifested in cognitive processes, emotional and motivational functioning, and their physiological and genetic underpinnings, and personal ways of interacting with the environment, (2) individual differences in personality structure and dynamics, (3) studies of intelligence and interindividual differences in cognitive functioning, and (4) development of personality differences as revealed by cross-sectional and longitudinal studies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信