Application of serum protein electrophoresis in multiple myeloma

Abstract

Multiple myeloma (MM) is a disease characterized by abnormal proliferation of clonal malignant plasma cells (myeloma cells) in the bone marrow and associated with the increase of monoclonal immunoglobulins (i.e, M-proteins). As the incidence of MM has been increasing year by year, with diverse clinical manifestations, the early diagnosis of MM is of great significance to the subsequent treatment and prognosis. Serum protein electrophoresis (SPE) is the most simple and effective method to isolate protein with the advantages of clear electrophoregram and band, high resolution and good repeatability. It is currently the first choice for the diagnosis of MM. To study the application of SPE to MM can provide a certain reference and help for the preliminary immunophenotyping, diagnosis and efficacy observation of MM.