Evaluation of Anti-diabetic and Anti-oxidant Activity of Centratherum anthelmintica in STZ – induced Diabetic Rats

The Internet Journal of Pharmacology Pub Date : 2007-12-31 DOI:10.5580/1b56

J. Shah, M. S. Patel, K. Patel, T. Gandhi

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引用次数: 10

Abstract

The present work is carried out to study the effect of Centratherum anthelminticum wild. kuntze (Asteaceae) on blood glucose level and antioxidant enzymes level in streptozotocin induced diabetic rats. Streptozotocin (STZ 50 mg/kg, i.p) induced diabetic rats were treated with methanolic extract of Centratherum anthelminticum (100 mg/kg; p.o.) for 28 days. Methanolic extract of Centratherum anthelminticum wild. Kuntze significantly prevented loss of body weight, decrease food and water intake. It showed significant prevention in elevation of glucose and significantly increased insulin level and showed prevention in increase in the cholesterol, triglyceride, LDL cholesterol, VLDL cholesterol levels in serum of diabetic rats. The treatment with methanolic extract of Centratherum anthelminticum also significantly prevented decrease in the HDL-cholesterol level and increase in urea and creatinine levels in diabetic rats compared to that of diabetic control. The chronic treatments with methanolic extract of CA significantly prevented the increase of malondialdehyde and prevent reduction of superoxide dismutase, catalase, and reduced glutathione levels. Histopathological study revealed that Centratherum anthelminticum extract provided significant protection against STZ induced degeneration in liver and kidney. This confirms the antidiabetic and antioxidant activity of Centratherum anthelminticum wild. kuntze in streptozotocin induced diabetic rats.

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驱虫草对STZ诱导的糖尿病大鼠的抗糖尿病和抗氧化活性评价

本研究是为了研究野生穿山甲的作用。苦参对链脲佐菌素诱导糖尿病大鼠血糖及抗氧化酶水平的影响。链脲佐菌素(STZ 50 mg/kg，灌胃)诱导的糖尿病大鼠用香薷甲醇提取物(100 mg/kg;p.o.) 28天。野生穿山甲甲醇提取物。Kuntze显著防止体重下降，减少食物和水的摄入量。对糖尿病大鼠血清中胆固醇、甘油三酯、LDL胆固醇、VLDL胆固醇水平升高有显著的预防作用，对血糖升高和胰岛素水平升高有显著的预防作用。与糖尿病对照组相比，用香茅甲醇提取物治疗糖尿病大鼠，也能显著防止高密度脂蛋白胆固醇水平的下降，尿素和肌酐水平的升高。长期用牛蒡醇提物处理可显著抑制丙二醛的升高，抑制超氧化物歧化酶、过氧化氢酶和还原性谷胱甘肽水平的降低。组织病理学研究表明，穿山甲提取物对STZ诱导的肝、肾变性具有明显的保护作用。这证实了野生穿山甲的抗糖尿病和抗氧化活性。链脲佐菌素诱导的糖尿病大鼠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Internet Journal of Pharmacology

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