P334 Fungal infections in patients with COVID-19 in 1-year pandemic 2020-2021 from Cote d'Ivoire

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 DOI:10.1093/mmy/myac072.P334

D. Koffi, A. Touré, Valerie Ira, M. F. Kouadjo, Reine M'boh, K. Sylla, M. Dosso

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引用次数: 0

Abstract

Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Background and Objectives The COVID-19 pandemic has caused significant public health problems both in Côte d'Ivoire and around the world. Among the different causes of morbidity and mortality in COVID-19 patients, the frequency and impact of co-infections are still little studied, especially in patients with acute respiratory distress syndrome (ARDS). However, people with severe COVID-19 infection are particularly vulnerable to bacterial and fungal infections. This study aims to determine the frequency and susceptibility profile of isolated fungi in severe COVID-19 patients living in west Africa. Methodology We conducted a retrospective observational study of COVID-19 patients who were tested for invasive fungal infections (IFI) between 2020 and 2021 in the laboratory of mycology at Pasteur Institute of Cote d'Ivoire. Results We received a total of 77 samples (from superficial specimens, deep sites, urine) collected from 35 patients admitted for severe COVID-19. The patients were predominantly female (n = 21, 60%) and had a median age of 54,5 years (range16-79 years). The mycological analysis for IFI diagnosis showed 20% of samples positive only for yeasts, 66.7% of which were Candida albicans and responsible for 90% of invasive infections in COVID-19 patients. No difference in fungal species was found regarding of the sex, age of the patients, and waves of the pandemic. Antifungal susceptibility testing revealed no resistance to antifungals (fluconazole, voriconazole, itraconazole, amphotericin B, and flucytosine) among Candida isolates. Conclusion These data show significant Candidiasis infection associated with the severe form of COVID-19. Given this prevalence of 20%, it is important for clinicians to remain vigilant and take proactive measures to prevent candidemia in patients with COVID-19. The widespread surveillance for fungal co-infections is still essential to reduce mortality associated with COVID-19.

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科特迪瓦2020-2021年大流行期间COVID-19患者的真菌感染情况

背景和目的2019冠状病毒病大流行在Côte科特迪瓦和世界各地都造成了重大的公共卫生问题。在COVID-19患者发病和死亡的不同原因中，合并感染的频率和影响仍然很少被研究，特别是在急性呼吸窘迫综合征(ARDS)患者中。然而，严重感染COVID-19的人特别容易受到细菌和真菌感染。本研究旨在确定西非重症COVID-19患者中分离真菌的频率和易感性特征。我们对2020年至2021年间在科特迪瓦巴斯德研究所真菌学实验室接受侵袭性真菌感染(IFI)检测的COVID-19患者进行了回顾性观察研究。结果我们共收到35例重症COVID-19患者的77份标本(表浅标本、深部标本、尿液标本)。患者以女性为主(n = 21,60%)，中位年龄54,5岁(范围16-79岁)。IFI诊断的真菌学分析显示，20%的样本仅呈酵母阳性，其中66.7%为白色念珠菌，占COVID-19患者侵袭性感染的90%。在真菌种类方面，没有发现患者性别、年龄和流行波的差异。念珠菌对氟康唑、伏立康唑、伊曲康唑、两性霉素B、氟胞嘧啶等抗真菌药物均无耐药性。结论念珠菌感染与重症COVID-19相关。鉴于这一患病率为20%，临床医生必须保持警惕并采取积极措施，预防COVID-19患者中出现念珠菌。广泛监测真菌合并感染对于降低与COVID-19相关的死亡率仍然至关重要。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.