The correlation between vitamin D levels and inflammation, as well as the Prognostic Nutritional Index (PNI), in people who are over the age of 60.

Abstract

Aim: Elderly populations often have insufficient vitamin D (vit-D), which may contribute to autoimmune diseases and inflammation. Few studies have examined vit-D levels and immune function in humans. The study looked at vit-D levels and inflammatory markers in older adults. Material and Methods: Retrospective research was done. The hospital's records were searched for the study's data. Participants were 65-year-olds who applied to the internal medicine outpatient clinic between May 2020 and May 2022. Each person's vit-D, CRP, Lymphocyte/Monocyte, Neutrophil/Lymphocyte, Platelet/Lymphocyte, Ferritin, and Prognostic nutritional index (PNI) levels were measured. Results: The information from 2118 patients was analyzed as part of the study. Of those patients, 324 met the requirements for participation in the research, and the participants' average age was 73.21 years, with a standard deviation of 5.24 years. The average level of vit-D found in people was 14.18 nmol/L, with a standard deviation of 6.14 nmol/L. It was discovered that there was a negative correlation that was statistically significant between the individuals' levels of vit-D and the ratio of CRP to MPV (p less than 0.05). Vit-D and PNI were found to have a correlation of r=0.205, which was found to be positive and significant (p <0.05). Every 0.721-unit increase in PNI will result in an additional 1 unit of 25(OH) vit-D. It was found that the CRP (mg/L) variable contributed significantly to the model, and it was discovered that the presence of 1 unit of 25(OH) vit-D was increased for every 0.202 unit decrease (p <0.05). Conclusion: Insufficient vitamin 25(OH)D is found in the elderly population. 25(OH) vit-D has a negative relationship with CRP (mg/L) and MPV (fL), but a positive relationship with PNI, an indicator of nutritional status. The study suggests that if an elderly person is disabled, nutritional supplements should be provided.