We Should Apply a “One Health” Approach to Understand and Treat Alzheimer’s Disease

A. White
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Abstract

Despite many decades of researches and large numbers of clinical trials, there remain no effective treatments for Alzheimer’s disease, a major degenerative ageing brain disorder. The potential treatments have focused on targeting the accumulation of amyloid beta-peptide in the brains of patients, but without success in slowing the disease. Many studies have now identified a large range of pathological changes (i.e. altered immune activity, mitochondrial impairment, abnormal microbiome), and links to the external environment (i.e. associations with infections, the influence of air pollution). While the concept of One Health (which considers links between the environment and human disease) has traditionally been applied to the understanding of the human infectious disease, it is argued here that the One Health approach should be adopted for Alzheimer’s disease. This would provide a far more holistic understanding of the disease, and its relationship to a growing number of exogenous factors, as well as could potentially lead to new treatment options targeted at the confluence of external influences, and internal molecular pathways.
我们应该用“同一个健康”的方法来认识和治疗阿尔茨海默病
尽管经过了几十年的研究和大量的临床试验,阿尔茨海默病仍然没有有效的治疗方法,这是一种主要的退行性衰老大脑疾病。潜在的治疗方法集中在针对患者大脑中淀粉样蛋白-肽的积累,但在减缓疾病方面没有成功。许多研究现已确定了大范围的病理变化(即免疫活性改变、线粒体损伤、微生物组异常)以及与外部环境的联系(即与感染的关联、空气污染的影响)。虽然统一健康的概念(考虑环境与人类疾病之间的联系)传统上被应用于对人类传染病的理解,但本文认为,对于阿尔茨海默病,应该采用统一健康的方法。这将提供对该疾病的更全面的了解,以及它与越来越多的外源性因素的关系,并可能导致针对外部影响和内部分子途径融合的新治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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