Transforming electronic plastics into bioadaptive 3D porous construct for advanced cell culture applications

IF 11.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Resources Conservation and Recycling Pub Date : 2023-11-06 DOI:10.1016/j.resconrec.2023.107297

Pujiang Shi , Tianle Huang , Hong Kit Lim , Chiew Kei Tan , Jong-Min Lee , Chor Yong Tay

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引用次数: 0

Abstract

Electronic plastics (e-plastics) are indispensable in modern society, but their low recycling rate and environmental persistence have raised significant concerns. Prevailing plastic recycling strategies are inadequate to fully capture the economic benefits inherent to e-plastics, providing limited incentives for recycling. Therefore, there is an urgent need to develop innovative approaches aimed at maximizing the capture of value from e-plastics. Herein, acrylonitrile butadiene styrene (ABS) from discarded keyboards was unconventionally “re-tooled” to produce highly porous bioadaptive 3D sponge-like constructs for advanced in vitro applications. The ABSponge was surface functionalized via layer-by-layer (LBL) electrostatic deposition method to generate 3D human breast, colorectal and bone cancer spheroids as a drug screening tool or adapted for co-culturing of cancer spheroids and cancer-associated-fibroblasts to emulate the complex tumor niche. Collectively, our findings reveal the promising potential of using discarded keyboards as a "waste-to-resource" feedstock for advanced in-vitro biotechnological applications, achieving waste reduction and maximizing value-capture.

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将电子塑料转化为生物适应性3D多孔结构，用于先进的细胞培养应用

电子塑料在现代社会中不可或缺，但其低回收率和环境持久性引起了人们的极大关注。现行的塑料回收战略不足以充分捕捉电子塑料固有的经济效益，为回收提供有限的激励。因此，迫切需要开发旨在最大限度地从电子塑料中获取价值的创新方法。在这项研究中，从废弃的键盘中提取的丙烯腈-丁二烯-苯乙烯(ABS)被非常规地“重新加工”，以生产出高度多孔的生物适应性3D海绵状结构，用于先进的体外应用。ABSponge通过层层(LBL)静电沉积法进行表面功能化，生成3D人类乳腺癌、结直肠癌和骨癌球体作为药物筛选工具，或适用于癌症球体和癌症相关成纤维细胞的共培养，以模拟复杂的肿瘤生态位。总的来说，我们的研究结果揭示了将废弃键盘作为先进体外生物技术应用的“废物转化为资源”原料的巨大潜力，从而实现废物减少和价值获取最大化。

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来源期刊

Resources Conservation and Recycling 环境科学-工程：环境

CiteScore

22.90

自引率

6.10%

发文量

625

审稿时长

23 days

期刊介绍： The journal Resources, Conservation & Recycling welcomes contributions from research, which consider sustainable management and conservation of resources. The journal prioritizes understanding the transformation processes crucial for transitioning toward more sustainable production and consumption systems. It highlights technological, economic, institutional, and policy aspects related to specific resource management practices such as conservation, recycling, and resource substitution, as well as broader strategies like improving resource productivity and restructuring production and consumption patterns. Contributions may address regional, national, or international scales and can range from individual resources or technologies to entire sectors or systems. Authors are encouraged to explore scientific and methodological issues alongside practical, environmental, and economic implications. However, manuscripts focusing solely on laboratory experiments without discussing their broader implications will not be considered for publication in the journal.