Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

IF 15.8 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Yumin Wang , Yongming Chen , Junjing Zhang , Yihui Yang , Joshua S. Fleishman , Yan Wang , Jinhua Wang , Jichao Chen , Yuanfang Li , Hongquan Wang
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引用次数: 0

Abstract

Cuproptosis is a newly identified form of cell death driven by copper. Recently, the role of copper and copper triggered cell death in the pathogenesis of cancers have attracted attentions. Cuproptosis has garnered enormous interest in cancer research communities because of its great potential for cancer therapy. Copper-based treatment exerts an inhibiting role in tumor growth and may open the door for the treatment of chemotherapy-insensitive tumors. In this review, we provide a critical analysis on copper homeostasis and the role of copper dysregulation in the development and progression of cancers. Then the core molecular mechanisms of cuproptosis and its role in cancer is discussed, followed by summarizing the current understanding of copper-based agents (copper chelators, copper ionophores, and copper complexes-based dynamic therapy) for cancer treatment. Additionally, we summarize the emerging data on copper complexes-based agents and copper ionophores to subdue tumor chemotherapy resistance in different types of cancers. We also review the small-molecule compounds and nanoparticles (NPs) that may kill cancer cells by inducing cuproptosis, which will shed new light on the development of anticancer drugs through inducing cuproptosis in the future. Finally, the important concepts and pressing questions of cuproptosis in future research that should be focused on were discussed. This review article suggests that targeting cuproptosis could be a novel antitumor therapy and treatment strategy to overcome cancer drug resistance.

cuprotosis:克服癌症耐药的新治疗靶点
铜增生是一种新发现的由铜驱动的细胞死亡形式。近年来,铜和铜在癌症发病过程中引发细胞死亡的作用引起了人们的关注。由于其在癌症治疗方面的巨大潜力,铜质增生引起了癌症研究界的极大兴趣。铜基治疗对肿瘤生长具有抑制作用,可能为化疗不敏感肿瘤的治疗打开大门。在这篇综述中,我们对铜稳态和铜失调在癌症发生和进展中的作用进行了批判性分析。然后讨论了铜沉淀的核心分子机制及其在癌症中的作用,然后总结了目前对铜基药物(铜螯合剂、铜离子载体和铜配合物动态疗法)治疗癌症的认识。此外,我们总结了基于铜络合物的药物和铜离子载体在不同类型癌症中抑制肿瘤化疗耐药的新数据。我们还综述了可能通过诱导铜变来杀死癌细胞的小分子化合物和纳米颗粒(NPs),这将为未来通过诱导铜变来开发抗癌药物提供新的思路。最后,讨论了铜骨成形术在未来研究中应重点关注的重要概念和紧迫问题。本文综述了靶向性铜增生可能是一种新的抗肿瘤治疗和治疗策略,以克服癌症的耐药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Drug Resistance Updates
Drug Resistance Updates 医学-药学
CiteScore
26.20
自引率
11.90%
发文量
32
审稿时长
29 days
期刊介绍: Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research
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