Effect of melatonin treatment on liver and thymus zinc levels in young and middle-aged rats

The Journal of Trace Elements in Experimental Medicine Pub Date : 2004-01-01 DOI:10.1002/jtra.10055

Güler Öztürk, K. Gonca Akbulut, Lale Afrasyap, Deniz Sevinç

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引用次数: 6

Abstract

Melatonin (MEL) is the main neurohormone of the pineal gland. Zinc (Zn) is an essential trace element that is required as a catalytic component for more than 200 enzymes. Both MEL and Zn are considered beneficial for anti-immunosenescence. Recent findings have shown that MEL can modulate Zn turnover. The aim of this study was to investigate the effect of MEL treatment on the tissue Zn levels in young (4 months) and middle-aged (14 months) rats. Male wistar rats received during 3 weeks subcutaneous injection of MEL (10 mg/kg). After 3 weeks, rats were decapitated and tissue samples were collected. Zn levels were measured by spectrophotometric assay. In conclusion, MEL decreased liver Zn levels both in young and middle-aged rats. In addition, Zn levels in young control group were significantly higher than middle-aged control group. However, MEL treatment increased thymus Zn levels in middle-aged group compared with the control. These findings indicate that tissue Zn levels are significantly affected by MEL treatment. J. Trace Elem. Exp. Med. 17:7580,

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褪黑素对中青年大鼠肝脏和胸腺锌水平的影响

褪黑素（MEL）是松果体的主要神经激素。锌（Zn）是一种必需的微量元素，是200多种酶所需的催化成分。MEL和Zn都被认为对抗免疫衰老有益。最近的研究结果表明MEL可以调节锌的周转。本研究的目的是研究MEL治疗对青年（4个月）和中年（14个月）大鼠组织锌水平的影响。雄性wistar大鼠在3周内皮下注射MEL（10mg/kg）。3周后，将大鼠斩首并收集组织样本。锌含量通过分光光度法测定。总之，MEL降低了青年和中年大鼠的肝脏锌水平。此外，青年对照组的锌水平显著高于中年对照组。然而，和对照组相比，MEL治疗增加了中年组胸腺锌水平。这些发现表明组织锌水平受到MEL治疗的显著影响。J.Trace Elem。Exp.Med.17:75-802004。©2004 Wiley-Liss，股份有限公司。

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The Journal of Trace Elements in Experimental Medicine

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