Disorders in blood coagulation in humans occupationally exposed to mercuric vapors

The Journal of Trace Elements in Experimental Medicine Pub Date : 2002-01-01 DOI:10.1002/jtra.1055

Ryszard Wierzbicki, Mirosław Prażanowski, Marta Michalska, Urszula Krajewska, Wojciech P. Mielicki

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引用次数: 23

Abstract

Changes in blood coagulation system were studied in humans that were occupationally exposed to mercuric vapors. The following parameters were analyzed: mercury concentration in plasma, thrombin generation, thrombin-antithrombin complexes, soluble fibrin monomers, factor XIII, protein C, platelet factor 4, and β-thromboglobulin. There was statistically significant increase in the activity of factor XIII, concentration of platelet factor 4 and thrombin generation in plasma of workers exposed to mercuric vapors as compared with unexposed controls. There was also an increase in thrombin-antithrombin complexes and β-thromboglobulin concentration accompanied by a decrease in protein C activity in the workers exposed to mercury. However, the last differences were not statistically significant. The data suggest that in humans exposed to mercuric vapors the hemostatic balance is shifted on the hypercoagulative side. J. Trace Elem. Exp. Med. 15:21–29, 2002. © 2002 Wiley-Liss, Inc.

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职业性接触汞蒸气的人体凝血障碍

研究了职业性接触汞蒸气的人体凝血系统的变化。分析了以下参数：血浆中汞浓度、凝血酶生成、凝血酶-抗凝血酶复合物、可溶性纤维蛋白单体、因子XIII、蛋白C、血小板因子4和β-血栓球蛋白。与未暴露的对照组相比，暴露于汞蒸汽的工人血浆中因子XIII的活性、血小板因子4的浓度和凝血酶的生成在统计学上显著增加。在接触汞的工人中，凝血酶-抗凝血酶复合物和β-血栓球蛋白浓度也增加，同时蛋白质C活性降低。然而，最后的差异在统计学上并不显著。数据表明，在暴露于汞蒸汽的人体中，止血平衡向高凝状态转移。J.Trace Elem。《实验医学》，2002年15月21日至29日。©2002 Wiley-Liss，股份有限公司。

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The Journal of Trace Elements in Experimental Medicine

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