Adrenergic Receptor Subtypes: Pharmacological Approaches

Esbenshade Timothy A., Minneman Kenneth P.
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引用次数: 4

Abstract

Although the existence of four distinct adrenergic receptor subtypes (α1, α2, β1, β2) has been recognized for more than 15 years, it has recently become clear that the adrenergic receptor family is much larger than previously suspected. Development of more selective agonists and antagonists and careful comparison of pharmacological properties have led to the realization that there are nine or more adrenergic receptor subtypes. Molecular cloning of many of these subtypes, discussed in an accompanying article, supports this conclusion. The adrenergic receptors fall into three major families (α1, α2, β) based on pharmacology, structure, and signal transduction, with at least three closely related members within each family. Here, we summarize the known pharmacological differences between these receptors and evaluate the best methods currently available for distinguishing these subtypes using selective drugs.

肾上腺素能受体亚型:药理学方法
尽管四种不同的肾上腺素能受体亚型(α1、α2、β1、β2)的存在已经被认识了超过15年,但最近很明显,肾上腺素能受体家族比以前怀疑的要大得多。更具选择性的激动剂和拮抗剂的开发以及药理学性质的仔细比较已经使人们认识到有九种或九种以上的肾上腺素能受体亚型。在随附的文章中讨论了许多这些亚型的分子克隆,支持了这一结论。肾上腺素受体根据药理学、结构和信号转导分为三大家族(α1、α2、β),每个家族中至少有三个密切相关的成员。在此,我们总结了这些受体之间已知的药理学差异,并评估了目前使用选择性药物区分这些亚型的最佳方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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