Cancer-Related Fatigue and Circulating Biomarkers in Breast Cancer Survivors.

Biological research for nursing Pub Date : 2024-04-01 Epub Date: 2023-11-10 DOI:10.1177/10998004231215777
David García-González, María Romero-Elías, Alejandro Álvarez-Bustos, Silvia Rosado-García, Antonio J Sánchez-López, Blanca Cantos, Constanza Maximiano, Miriam Méndez, Marta Méndez-Otero, Héctor Cebolla, Jesús García-Foncillas, Ana Ruiz-Casado
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Abstract

Purpose: Cancer-related fatigue (CRF) is the most common and disruptive symptom experienced by cancer survivors and because of its frequency and severity is especially worrisome in breast cancer survivors (BCS). Despite a great deal of research, the mechanisms underlying CRF have not been determined. The present study aims to describe associations between CRF in BCS and different blood biomarkers.

Methods: A descriptive and cross-sectional study was conducted. A set of biomarkers assessing inflammation were measured in BCS: C-reactive protein (CRP), neutrophil-lymphocyte ratio (NLR), IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor (TNF); HPA axis dysfunction (cortisol), autonomic dysfunction (noradrenaline); oxidative stress (8-OH deoxyguanosine); insulin resistance markers (insulin, IGF-I, IGFBP3) and sexual hormones (estrogens, progesterone, testosterone).

Results: NLR (p = .00) and cortisol (p = .02) were positive and negatively associated with CRF, respectively. The rest of the blood markers were not associated with CRF.

Conclusion: Our results increase the evidence on pathophysiological mechanisms driving CRF in BCS. However, longitudinal studies are needed to explore the role of these factors as potential causal mechanisms.

乳腺癌症幸存者的癌症相关疲劳和循环生物标志物。
目的:癌症相关疲劳(CRF)是癌症幸存者经历的最常见和最具破坏性的症状,由于其频率和严重程度,癌症幸存者(BCS)尤其令人担忧。尽管进行了大量的研究,CRF的潜在机制尚未确定。本研究旨在描述BCS中CRF与不同血液生物标志物之间的关系。方法:采用描述性和横断面研究。在BCS中测量了一组评估炎症的生物标志物:C反应蛋白(CRP)、中性粒细胞淋巴细胞比率(NLR)、IL-1β、IL-6、IL-8、IL-10、肿瘤坏死因子(TNF);HPA轴功能障碍(皮质醇)、自主神经功能障碍(去甲肾上腺素);氧化应激(8-OH脱氧鸟苷);胰岛素抵抗标志物(胰岛素、IGF-I、IGFBP3)和性激素(雌激素、孕酮、睾酮)。结果:NLR(p=0.00)和皮质醇(p=0.02)分别与CRF呈正相关和负相关。其余血液标志物与CRF无关。结论:我们的研究结果为BCS CRF的病理生理机制提供了更多的证据。然而,需要进行纵向研究来探索这些因素作为潜在因果机制的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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